Study could spur wider use of prenatal gene tests

A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.

A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.

"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."

He led the federally funded study, published in Thursday's New England Journal of Medicine.

A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.

The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.

"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.

Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.

The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.

The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.

In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.

"Some did it for anxiety — they just wanted more information about their child," Wapner said.

Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.

"That's a lot. That's huge," Klugman said.

Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.

Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.

In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.

Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.

"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.

"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.

The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.

The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.

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Medical journal: http://www.nejm.org

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Bodies Found in Hunt for Missing Iowa Cousins

Nearly five months after Iowa cousins Lyric Cook and Elizabeth Collins disappeared, the girls' families have been told two bodies were found by hunters in a wooded area, though the identities of the bodies have not been confirmed, authorities said.

Capt. Rick Abben of the Black Hawk County Sheriff's Office said at a press conference this afternoon that the bodies are being transported to the state's medical office in Ankeny, Iowa, for positive identification.

"It's definitely not the outcome that we wanted, obviously," Abben said. "This is a difficult thing for us to go through."

Lyric, 11, and Elizabeth , 9, vanished shortly after noon on July 13 while on a bike ride in the small town of Evansdale, Iowa, triggering a massive search that brought the town to a standstill. The girls' bicycles and a purse were quickly found near Meyers Lake, but there was no sign of the girls.

PHOTOS From ABC News Affiliate KCRG: The Search for Lyric & Elizabeth

Black Hawk County Police/AP Photo

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On the two-month anniversary of the girls' disappearance, local residents held a prayer vigil and authorities urged members of the public to provide any new information that might help them solve the case.

Authorities said the girls left Elizabeth's house in Evansdale around 12:15 p.m., were spotted at approximately 12:23 p.m. at a nearby intersection and then were seen between 12:30 and 1 p.m. on a road by the lake.

During the following week, authorities canvassed the area and drained the town's lake. Lyric's estranged parents, Misty and Dan Morrissey, at one point became the subject of intense police scrutiny because of their criminal pasts and their lack of cooperation.

Over the summer, the families received a boost when Elizabeth Smart, one of the country's most famous kidnapping survivors, offered some words of encouragement. Police found Smart after a nine-month search in Utah a decade ago.

"For as many bad things that we hear about that happen, for as many kidnappings and terrible stories about finding the remains of children, why can't these girls be the exception?" Smart told the Des Moines Register.

Elizabeth's mother, Heather Collins, told ABC News' Alex Perez in July that the wait for the girls to reappear was an agonizing one.

"A day doesn't seem like a normal day," Collins said. "It's just like it doesn't stop. It keeps dragging and dragging. You're just waiting for a time to go up to your room. You're just waiting, waiting, waiting."

"Whoever's out there, we're just begging you to bring our girls back home," she said.

A $50,000 reward had been offered for information that led to the arrest and conviction of the person responsible for the girls' disappearance.

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Rivals clash as Mursi deputy seeks end to Egypt crisis

CAIRO (Reuters) - Islamists battled with protesters outside Egyptian President Mohamed Mursi's palace on Thursday, after his vice president suggested amendments could be agreed to the draft constitution that has divided the nation.

Fires burned in the streets near the palace perimeter where opponents and supporters of Mursi threw stones and petrol bombs. Riot police tried to separate the two sides, but failed to halt fighting that extended from Wednesday into the early morning.

Residents, frustrated that police had not calmed the streets, set up makeshift road blocks nearby to check passers-by, scenes reminiscent of the popular uprising that toppled Mursi's autocratic predecessor Hosni Mubarak.

Three people were killed and 350 injured in the clashes, according to a statement released by the Ministry of Health.

"No to dictatorship," Mursi's opponents chanted, while their rivals chanted: "Defending Mursi is defending Islam."

Mursi's opponents accused him of creating a new autocracy by awarding himself extraordinary powers in a decree on November 22 and were further angered when an Islamist-dominated assembly pushed through a draft constitution that opponents said did not properly represent the aspirations of the whole nation.

The United States, worried about the stability of a state that has a peace deal with Israel and to which it gives $1.3 billion in military aid each year, called for dialogue.

A presidential source said Mursi was expected to make a statement later on Thursday. His opponents had earlier called on him to address the nation to help calm the streets.

Bidding to end the worst crisis since Mursi took office less than six months ago, Vice President Mahmoud Mekky said amendments to disputed articles in the constitution could be agreed with the opposition. A written agreement could then go to parliament, to be elected after a referendum on the constitution on December 15.

"There must be consensus," he told a news conference inside the presidential palace as fighting raged outside on Wednesday evening, saying opposition demands had to be respected.

PROTESTS SPREAD

Prime Minister Hisham Kandil called for calm to "give the opportunity" for efforts underway to start a national dialogue.

Protests spread to other cities, and offices of the Muslim Brotherhood's political party in Ismailia and Suez were torched.

But Mursi has shown no sign of buckling under pressure from protestors, confident that the Islamists, who have dominated both elections since Mubarak was overthrown in February 2011, can win the referendum and parliamentary election to follow.

On top of the support of the Brotherhood, which backed him for the presidency in the June election, Mursi may also be able to rely on a popular yearning for stability and economic revival after almost two years of political turmoil.

Egypt's opposition coalition blamed Mursi for the violence and said it was ready for dialogue if the Islamist leader scrapped the decree that gave him wide powers and shielded his decisions from judicial review.

"Today what is happening in the Egyptian street, polarization and division, is something that could and is actually drawing us to violence and could draw us to something worse," opposition coordinator Mohamed ElBaradei said on Wednesday.

"We are ready for dialogue if the constitutional decree is cancelled ... and the referendum on this constitution is postponed," he told a news conference.

But liberals, leftists, Christians, ex-Mubarak followers and others opposed to Mursi have yet to generate a mass movement or a grassroots base to challenge the Brotherhood.

'REAL DANGER'

Opposition leaders have previously urged Mursi to retract the decree, defer the referendum and agree to revise the constitution, but have not echoed calls from street protesters for his overthrow and the "downfall of the regime".

Mursi has said his decree was needed to prevent courts still full of judges appointed by Mubarak from derailing a constitution vital for Egypt's political transition.

Mekky said street mobilization by both sides posed a "real danger" to Egypt. "If we do not put a stop to this phenomenon right away ... where are we headed? We must calm down."

U.S. Secretary of State Hillary Clinton weighed into Egypt's political debate, saying dialogue was urgently needed on the new constitution, which should "respect the rights of all citizens".

Clinton and Mursi worked together last month to broker a truce between Israel and Hamas Islamists in the Gaza Strip.

British Foreign Secretary William Hague called for restraint on all sides. He said Egypt's authorities had to make progress on the transition in an "inclusive manner" and urged dialogue.

Both Islamists and their opponents have staged big shows of strength on the streets since Mursi's decree, each bringing out tens of thousands of people.

State institutions, with the partial exception of the judiciary, have mostly fallen in behind Mursi.

The army, the muscle behind all previous Egyptian presidents in the republic's six-decade history, has gone back to barracks, having apparently lost its appetite to intervene in politics.

(Additional reporting by Yasmine Saleh and Marwa Awad; Writing by Edmund Blair; Editing by Will Waterman)

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Australian economy grows 0.5% in Sep quarter

SYDNEY: Australia's economy grew 0.5 per cent in the three months to September and 3.1 per cent from a year earlier, data showed Wednesday, with China's slowdown dampening growth.

The Australian Bureau of Statistics said gross domestic product (GDP) grew a seasonally adjusted 0.5 per cent in the quarter, in line with expectations, driven by the mining and manufacturing sectors.

It compares with growth of 0.6 per cent in the three months to June and year-on-year growth of 3.7 per cent last quarter, lending weight to the central bank's decision to lower interest rates on Tuesday to stimulate the economy.

Mining contributed 0.4 per cent to quarterly GDP growth, despite a plunge in commodity prices due to a cooling in China's economy that saw a 4.0 per cent drop in Australia's terms of trade -- the value of its exports against its imports.

Private business investment accounted for 0.5 per cent of GDP growth and consumer spending added 0.2 per cent. Falling government spending detracted 0.5 per cent.

The Reserve Bank of Australia slashed the official interest rate by 25 basis points to 3.0 per cent this week -- their equal lowest since RBA independence in the early 1990s.

- AFP/ck

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FDI in retail will not help farmers: V K Singh

NEW DELHI: Former Army chief Gen V K Singh slammed the government's decision to bring in FDI in multi-brand retail saying the move would not benefit farmers as procurement would be outsourced from other countries at cheaper prices.

Joining in a Parliament gherao by farmers under the banner of the Rashtriya Kisan Mazdoor Sangathan (RKMS) on Tuesday, Singh demanded that the Rangarajan committee report on freeing the sugar sector be junked.

On FDI, he said even when Pepsico came to India, it was said that it would help farmers but that was never the case. "In India, we have an excellent model in terms of Amul to empower farmers. We can bring about the same change what people are trying to bring through FDI by making suitable modifications to the Amul model," he said.

Singh said farmers would not be benefited because the multi-brand retailers would import cheap items from other countries and not procure them from within India.

On the Rangarajan committee report, Singh said, "No politician has worked for farmers. They get votes from you people by promising many things, but they forget that there is a community called farmers after the elections. Next time, when you go to the polling booth, think who will fight for you and then vote only for that person.''

However, the former Army chief said he was not supporting any particular party but was only asking farmers to keep their "betterment in mind" before pressing the EVM button.

The protesters gathered near Parliament Street police station, less than a kilometre from Parliament House, and raised slogans demanding that the report be rejected.

RKMS's V M Singh said there was a need to raise a 'Kisan Sena' in the country that would fight for farmers' rights. He added that if the government did not pay heed to the farmers' demands, they would go on indefinite dharna at Boat Club.

Dubbing as "anti-farmer" the Rangarajan committee report which has recommended phased decontrol of the highly regulated Rs 80,000-crore sugar industry, he said the prime minister and Parliament should not accept the report.

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Study: Drug coverage to vary under health law

WASHINGTON (AP) — A new study says basic prescription drug coverage could vary dramatically from state to state under President Barack Obama's health care overhaul.

That's because states get to set benefits for private health plans that will be offered starting in 2014 through new insurance exchanges.

The study out Tuesday from the market analysis firm Avalere Health found that some states will require coverage of virtually all FDA-approved drugs, while others will only require coverage of about half of medications.

Consumers will still have access to essential medications, but some may not have as much choice.

Connecticut, Virginia and Arizona will be among the states with the most generous coverage, while California, Minnesota and North Carolina will be among states with the most limited.

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Avalere Health: http://tinyurl.com/d3b3hfv

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Tasting DNA-Altered Salmon That May Hit US Plates

Deep in the rain forests of Panama, in a secret location behind padlocked gates, barbed-wire fences and over a rickety wooden bridge, grows what could be the most debated food product of our time.

It may look like the 1993 hit movie "Jurassic Park," but at this real-life freshwater farm scientists are altering the genes not of dinosaurs -- but of fish.

They are growing a new DNA-altered saltwater fish in the mountains, far from the sea -- a salmon that could be the first genetically altered animal protein approved for the world to eat. If it is approved, this would be a landmark change for human food.

But it is one critics call "Frankenfish."

"The idea of changing an animal form, I think, is really creepy," said Gary Hirshberg, founder of Stonyfield Farm, an organic dairy farm. "When you move the DNA from a species into another species ... you create a new life form that's so new and so unique that you can get a patent for it."

And until now, AquaBounty, the multinational biotech company that for 20 years has been developing this giant fish, has kept it under close wraps.

The press has never been invited to its Prince Edward Island laboratory on the Canadian maritime coast, and its fish farm location in Panama has been kept secret out of fear of sabotage.

The Food and Drug Administration has seen it, but few from the outside. In fact, the last public tour of any kind was four years ago.

AquaBounty Creates 'Fort Knox for Fish'

ABC News was given exclusive access to see the facilities up close and an opportunity to taste this mysterious fish that FDA scientists say "is as safe as food from conventional Atlantic salmon," although have yet to officially approve it for public sale.

Ron Stotish, the president and CEO of AquaBounty Technologies, the company that created and hopes to market the eggs of this salmon to independent fish farms around the world, told ABC News it has employed bio-security measures, creating a "Fort Knox for fish," to ensure safety for the fish and prevent cross-contamination with the wild.

Entry to both facilities begins with body suits and iodine baths for shoes, which serves to keep the fish safe from germs.

Inside these protected tanks, America gets the first up-close look at the final product, the fish that has the food police up in arms.

"These are very healthy, beautiful Atlantic salmon," Stotish said.

With one big difference -- the growth rate of a regular salmon compared to that of an AquaBounty genetically modified fish.

While the AquaBounty fish do not grow to a size larger than normal salmon, they get to full size much faster, cutting costs for producers.

A normal-size 1-year-old Atlantic salmon averages 10 inches long, while the genetically modified fish at the same age is more than two times larger, coming in at 24 inches.

Salmon is the second most popular seafood in America. According to the National Oceanic and Atmospheric Administration, the average size of an Atlantic salmon is 28 inches to 30 inches and 8 pounds to 12 pounds after two years at sea.

How do they accomplish the accelerated growth?

"They differ by a single gene," Stotish said.

But, it's that single gene change that makes the DNA-altered salmon grow much faster than a normal Atlantic salmon, because it's really three fish in one.

AquaBounty scientists have taken a growth gene from the Chinook salmon and inserted it into the DNA of the Atlantic salmon because Chinooks grow fast from birth, while Atlantics do not.

"Salmon in their first two years of life grow very slowly," Stotish said.

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Police raid highway operator over Japan tunnel collapse

TOKYO: Japanese police on Tuesday raided offices belonging to a highway operator over a weekend tunnel collapse that killed nine people.

More than eight officers from the Yamanashi Police Department entered the office of NEXCO in Hachioji, western Tokyo, a spokesman for the highway operator said.

"We are fully cooperating with the authorities over the accident," the spokesman told AFP.

Police also plan to raid more of the company's offices in connection with the tragedy at the Sasago tunnel, which passes through hills near Mount Fuji, Japanese broadcaster NHK said.

On Monday, the Japanese government ordered inspections of ageing highway tunnels following the accident as suspicion over the cause of the accident centred on decaying ceiling supports.

- AFP/fa/ck

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Patels clearly hold the key

AHMEDABAD: Ever since former Congress chief minister Madhavsinh Solanki formulated KHAM - a political axis comprising kshatriyas, harijans, adivasis and Muslims - that helped Congress a record 149 seats in 1985 - Patels have steadily gravitated towards the BJP. The Congress has not tasted power in Gujarat after 1990 thanks to rising Patel power.

In all, there are 148 Patel candidates in fray representing the three main players - BJP, Congress and GPP. Leuvas, a Patel sub-caste which Keshubhai Patel represents, dominate at least 40 out of the total 182 seats in Gujarat, mostly in Saurashtra, south and central Gujarat. Leuva Patels constitute anything between 20% to 50% votes in these 40 seats. Kadva Patels are in large numbers in north Gujarat. With Keshubhai threatening to make a dent into BJP's vote share, mainly due to the clout he enjoys in his community, BJP has also fielded a large number of Patels. But BJP's Patel leaders like Purshottam Rupala, Anandiben Patel and RC Faldu are no match to Keshubhai.

Modi tried his best to rope in Naresh Patel, a community leader who has become a rallying point for the economically powerful community, which now wants to re-gain its lost political glory by helping both the GPP and Congress.

Besides, the Bharatiya Kisan Sangh, which has a large following among Patel farmers, is aggressively campaigning against Modi. VHP leader Pravin Togadia, himself a Leuva Patel, is likely to make matters worse for the Gujarat CM.

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Fossil fuel subsidies in focus at climate talks

DOHA, Qatar (AP) — Hassan al-Kubaisi considers it a gift from above that drivers in oil- and gas-rich Qatar only have to pay $1 per gallon at the pump.

"Thank God that our country is an oil producer and the price of gasoline is one of the lowest," al-Kubaisi said, filling up his Toyota Land Cruiser at a gas station in Doha. "God has given us a blessing."

To those looking for a global response to climate change, it's more like a curse.

Qatar — the host of U.N. climate talks that entered their final week Monday — is among dozens of countries that keep gas prices artificially low through subsidies that exceeded $500 billion globally last year. Renewable energy worldwide received six times less support — an imbalance that is just starting to earn attention in the divisive negotiations on curbing the carbon emissions blamed for heating the planet.

"We need to stop funding the problem, and start funding the solution," said Steve Kretzmann, of Oil Change International, an advocacy group for clean energy.

His group presented research Monday showing that in addition to the fuel subsidies in developing countries, rich nations in 2011 gave more than $58 billion in tax breaks and other production subsidies to the fossil fuel industry. The U.S. figure was $13 billion.

The Paris-based Organization for Economic Cooperation and Development has calculated that removing fossil fuel subsidies could reduce carbon emissions by more than 10 percent by 2050.

Yet the argument is just recently gaining traction in climate negotiations, which in two decades have failed to halt the rising temperatures that are melting Arctic ice, raising sea levels and shifting weather patterns with impacts on droughts and floods.

In Doha, the talks have been slowed by wrangling over financial aid to help poor countries cope with global warming and how to divide carbon emissions rights until 2020 when a new planned climate treaty is supposed to enter force. Calls are now intensifying to include fossil fuel subsidies as a key part of the discussion.

"I think it is manifestly clear ... that this is a massive missing piece of the climate change jigsaw puzzle," said Tim Groser, New Zealand's minister for climate change.

He is spearheading an initiative backed by Scandinavian countries and some developing countries to put fuel subsidies on the agenda in various forums, citing the U.N. talks as a "natural home" for the debate.

The G-20 called for their elimination in 2009, and the issue also came up at the U.N. earth summit in Rio de Janeiro earlier this year. Frustrated that not much has happened since, European Union climate commissioner Connie Hedegaard said Monday she planned to raise the issue with environment ministers on the sidelines of the talks in Doha.

Many developing countries are positive toward phasing out fossil fuel subsidies, not just to protect the climate but to balance budgets. Subsidies introduced as a form of welfare benefit decades ago have become an increasing burden to many countries as oil prices soar.

"We are reviewing the subsidy periodically in the context of the total economy for Qatar," the tiny Persian gulf country's energy minister, Mohammed bin Saleh al-Sada, told reporters Monday.

Qatar's National Development Strategy 2011-2016 states it more bluntly, saying fuel subsides are "at odds with the aspirations" and sustainability objectives of the wealthy emirate.

The problem is that getting rid of them comes with a heavy political price.

When Jordan raised fuel prices last month, angry crowds poured into the streets, torching police cars, government offices and private banks in the most sustained protests to hit the country since the start of the Arab unrest. One person was killed and 75 others were injured in the violence.

Nigeria, Indonesia, India and Sudan have also seen violent protests this year as governments tried to bring fuel prices closer to market rates.

Iran has used a phased approach to lift fuel subsidies over the past several years, but its pump prices remain among the cheapest in the world.

"People perceive it as something that the government is taking away from them," said Kretzmann. "The trick is we need to do it in a way that doesn't harm the poor."

The International Energy Agency found in 2010 that fuel subsidies are not an effective measure against poverty because only 8 percent of such subsidies reached the bottom 20 percent of income earners.

The IEA, which only looked at consumption subsidies, this year said they "remain most prevalent in the Middle East and North Africa, where momentum toward their reform appears to have been lost."

In the U.S., environmental groups say fossil fuel subsidies include tax breaks, the foreign tax credit and the credit for production of nonconventional fuels.

Industry groups, like the Independent Petroleum Association of America, are against removing such support, saying that would harm smaller companies, rather than the big oil giants.

In Doha, Mohammed Adow, a climate activist with Christian Aid, called all fuel subsidies "reckless and dangerous," but described removing subsidies on the production side as "low-hanging fruit" for governments if they are serious about dealing with climate change.

"It's going to oil and coal companies that don't need it in the first place," he said.

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Associated Press writers Abdullah Rebhy in Doha, Qatar, and Brian Murphy in Dubai, United Arab Emirates, contributed to this report

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Karl Ritter can be reached at www.twitter.com/karl_ritter

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